SERS Detection of Ricin B‑Chain via N‑Acetyl-Galactosamine Glycopolymers

A novel sensing scheme is exemplified through the detection of ricin B-chain (RBC) in water and liquid food matrices: surface-enhanced Raman spectroscopy (SERS) coupled with an N-acetyl-galactosamine glycopolymer capture layer. The sensing scheme’s detection limit was well below that of the predicte...

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Bibliographic Details
Published in:ACS sensors 2016-07, Vol.1 (7), p.842-846
Main Authors: Szlag, Victoria M, Styles, Matthew J, Madison, Lindsey R, Campos, Antonio R, Wagh, Bharat, Sprouse, Dustin, Schatz, George C, Reineke, Theresa M, Haynes, Christy L
Format: Article
Language:English
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Summary:A novel sensing scheme is exemplified through the detection of ricin B-chain (RBC) in water and liquid food matrices: surface-enhanced Raman spectroscopy (SERS) coupled with an N-acetyl-galactosamine glycopolymer capture layer. The sensing scheme’s detection limit was well below that of the predicted oral exposure limit. Theoretical predictions of the normal Raman spectrum of the glycomonomer give insight into polymer–RBC intermolecular interactions.
ISSN:2379-3694
2379-3694
DOI:10.1021/acssensors.6b00209