Telescoped Two-Step Continuous-Flow Synthesis of Vanillin

This paper presents a novel telescoped continuous-flow process for vanillin synthesis that involves the use of two flow reactors, three in-line liquid–liquid extraction (LLE) systems, and an in-line gas–liquid separator. The highly efficient flow reaction process achieves a space-time yield that is...

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Bibliographic Details
Published in:ACS sustainable chemistry & engineering 2023-11, Vol.11 (45), p.16322-16329
Main Authors: Ichitsuka, Tomohiro, Sato, Masahide, Miura, Shiho, Makino, Takashi, Ishizaka, Takayuki
Format: Article
Language:English
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Summary:This paper presents a novel telescoped continuous-flow process for vanillin synthesis that involves the use of two flow reactors, three in-line liquid–liquid extraction (LLE) systems, and an in-line gas–liquid separator. The highly efficient flow reaction process achieves a space-time yield that is at least 24 times higher than that of the conventional process. The optimized in-line LLE system enables the recycling of raw materials and solvents while reducing solvent usage, which results in a 50% reduction of process mass intensity. Employing this highly efficient, green process results in the continuous synthesis of vanillin, with a yield of 71% and a throughput of 2.3 g·h–1.
ISSN:2168-0485
2168-0485
DOI:10.1021/acssuschemeng.3c05168