Methods for the Topographical Patterning and Patterned Surface Modification of Hydrogels Based on Hydroxyethyl Methacrylate

Hydrogels have gained broad acceptance as a class of biocompatible materials. In this paper, we report the topographic patterning and regiospecific functionalization of hydrogel surfaces. Both photolithography and soft lithography are combined in a hybrid process to form these topographic features....

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Bibliographic Details
Published in:Biomacromolecules 2003-09, Vol.4 (5), p.1126-1131
Main Authors: Yu, Tianyue, Ober, Christopher K
Format: Article
Language:English
Subjects:
Applied sciences
Biocompatible Materials - chemistry
Exact sciences and technology
Hydrogels - chemistry
Methacrylates - chemistry
Organic polymers
Physicochemistry of polymers
Properties and characterization
Proteins - chemistry
Solution and gel properties
Surface Properties
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Summary:Hydrogels have gained broad acceptance as a class of biocompatible materials. In this paper, we report the topographic patterning and regiospecific functionalization of hydrogel surfaces. Both photolithography and soft lithography are combined in a hybrid process to form these topographic features. By functionalization of a base layer surface followed by lithographic patterning steps, it is possible to introduce chemical functions to specific regions of the patterned surface. The model systems investigated were based on 2-hydroxyethyl methacrylate (HEMA), which is well-known for its low toxicity and widespread use in biomedical applications. Tests of Ni−NTA modified hydrogel surfaces showed successful binding of fluorescently labeled proteins to selected regions of the patterned hydrogel surface. These processes can be expanded to a wide range of monomer systems.
ISSN:1525-7797
1526-4602
DOI:10.1021/bm034079m