In Vitro Biocompatibility Studies of Antibacterial Quaternary Polymers

Quaternized copolymers of 4-vinylpyridine and poly(ethylene glycol) methyl ether methacrylate are known to have antibacterial properties and have displayed biocompatibility in red blood cell hemolysis assays. The results from hemolysis assays have shown substantial promise, but the technique is rudi...

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Bibliographic Details
Published in:Biomacromolecules 2009-09, Vol.10 (9), p.2550-2555
Main Authors: Stratton, Thomas R, Rickus, Jenna L, Youngblood, Jeffrey P
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - toxicity
Applied sciences
Biocompatible Materials - pharmacology
Biocompatible Materials - toxicity
Biological properties
Caco-2 Cells
Cell Survival - drug effects
Epithelial Cells - cytology
Epithelial Cells - drug effects
Exact sciences and technology
Humans
Materials Testing
Microbial Sensitivity Tests
Organic polymers
Physicochemistry of polymers
Polymers - pharmacology
Polymers - toxicity
Properties and characterization
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Description
Summary:Quaternized copolymers of 4-vinylpyridine and poly(ethylene glycol) methyl ether methacrylate are known to have antibacterial properties and have displayed biocompatibility in red blood cell hemolysis assays. The results from hemolysis assays have shown substantial promise, but the technique is rudimentary and only a first step toward the determination of biocompatibility. The present paper further explores the biocompatibility of these copolymers through comprehensive cell viability assays performed on Caco-2 human epithelial cells cultivated in vitro. We have shown that these copolymers are biocompatible at concentrations above their minimum bactericidal concentrations, leading to selectivity values that compare well with other microbicidal products.
ISSN:1525-7797
1526-4602
DOI:10.1021/bm9005003