Crystallization in Polymorphic Systems:  The Solution-Mediated Transformation of β to α Glycine

The crystallization and subsequent polymorphic transformation from the β to the α form of glycine has been studied using optical microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy techniques. The crystal structure and morphology of β glycine have been determined, and the infl...

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Bibliographic Details
Published in:Crystal growth & design 2003-01, Vol.3 (1), p.53-60
Main Authors: Ferrari, Elena S, Davey, Roger J, Cross, Wendy I, Gillon, Amy L, Towler, Christopher S
Format: Article
Language:English
Subjects:
Condensed matter: structure, mechanical and thermal properties
Cross-disciplinary physics: materials science
rheology
Crystalline state (including molecular motions in solids)
Crystallographic aspects of phase transformations
pressure effects
Exact sciences and technology
Growth from solutions
Materials science
Methods of crystal growth
physics of crystal growth
Physics
Structure of solids and liquids
crystallography
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Summary:The crystallization and subsequent polymorphic transformation from the β to the α form of glycine has been studied using optical microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy techniques. The crystal structure and morphology of β glycine have been determined, and the influence of solvent, solubility, and process scale on its solvent-mediated transformation to the α form was quantified. It is concluded that for the low solubility environments used in this study, the rate-determining step in the transformation process is the dissolution rate of the metastable β polymorph.
ISSN:1528-7483
1528-7505
DOI:10.1021/cg025561b