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Variable Temperature Studies of a Polymorphic System Comprising Two Pairs of Enantiotropically Related Forms: [S,S]-Ethambutol Dihydrochloride
Of the four known polymorphs of [S,S]-ethambutol dihydrochloride, two transform in an enantiotropic single-crystal-to-single-crystal phase transformation from Form II to Form I on heating. The crystal structures of these two forms have been solved and compared. Because the other two forms are metast...
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Published in: | Crystal growth & design 2004-05, Vol.4 (3), p.431-439 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Of the four known polymorphs of [S,S]-ethambutol dihydrochloride, two transform in an enantiotropic single-crystal-to-single-crystal phase transformation from Form II to Form I on heating. The crystal structures of these two forms have been solved and compared. Because the other two forms are metastable and are only obtained from the melt, single-crystal data could not be obtained on them. However, all four forms have been characterized, and their relative thermodynamic relationships have been investigated by variable-temperature solid-state 13C NMR, variable-temperature powder X-ray diffraction studies, differential scanning calorimetry, and optical microscopy. |
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ISSN: | 1528-7483 1528-7505 |
DOI: | 10.1021/cg0341959 |