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Au-Doped Magnetic Silica Nanotube for Binding of Cysteine-Containing Proteins
The Au-doped magnetic silica nanotube (Au-MSNT) was fabricated by sol−gel transcription and its binding ability for proteins was carried out by TEM, FT-IR, and confocal microscope. The nickel nanoparticles with 3.5 ± 1.0 nm are homogeneously deposited on the inner side of a silica nanotube (SNT) wit...
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Published in: | Chemistry of materials 2008-06, Vol.20 (12), p.3809-3813 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The Au-doped magnetic silica nanotube (Au-MSNT) was fabricated by sol−gel transcription and its binding ability for proteins was carried out by TEM, FT-IR, and confocal microscope. The nickel nanoparticles with 3.5 ± 1.0 nm are homogeneously deposited on the inner side of a silica nanotube (SNT) with 220 nm diameter. In addition, the Au-MSNT clearly revealed the Au nanoparticles with 9.3 ± 2.0 nm diameter. The Au-MSNT carried out the binding ability for protein as a guest molecule. The Au-MSNT acted as a receptor for the selective molecular recognition of biomolecules, particularly proteins containing cysteine. On the other hand, ubiquitin, which has no cysteine groups, was not immobilized onto the Au-MSNT. These results indicate that the Au-MSNT is efficiently recognized by the cysteine-containing protein. |
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ISSN: | 0897-4756 1520-5002 |
DOI: | 10.1021/cm703674d |