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Au-Doped Magnetic Silica Nanotube for Binding of Cysteine-Containing Proteins

The Au-doped magnetic silica nanotube (Au-MSNT) was fabricated by sol−gel transcription and its binding ability for proteins was carried out by TEM, FT-IR, and confocal microscope. The nickel nanoparticles with 3.5 ± 1.0 nm are homogeneously deposited on the inner side of a silica nanotube (SNT) wit...

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Bibliographic Details
Published in:Chemistry of materials 2008-06, Vol.20 (12), p.3809-3813
Main Authors: Bae, Doo Ri, Lee, Soo Jin, Han, Sang Woo, Lim, Jung Mi, Kang, Dongmin, Jung, Jong Hwa
Format: Article
Language:English
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Summary:The Au-doped magnetic silica nanotube (Au-MSNT) was fabricated by sol−gel transcription and its binding ability for proteins was carried out by TEM, FT-IR, and confocal microscope. The nickel nanoparticles with 3.5 ± 1.0 nm are homogeneously deposited on the inner side of a silica nanotube (SNT) with 220 nm diameter. In addition, the Au-MSNT clearly revealed the Au nanoparticles with 9.3 ± 2.0 nm diameter. The Au-MSNT carried out the binding ability for protein as a guest molecule. The Au-MSNT acted as a receptor for the selective molecular recognition of biomolecules, particularly proteins containing cysteine. On the other hand, ubiquitin, which has no cysteine groups, was not immobilized onto the Au-MSNT. These results indicate that the Au-MSNT is efficiently recognized by the cysteine-containing protein.
ISSN:0897-4756
1520-5002
DOI:10.1021/cm703674d