Gold-Catalyzed Synthesis of 3-Arylindoles via Annulation of Nitrosoarenes and Alkynes

We have successfully developed a Au-catalyzed annulation method to produce substituted 3-arylindoles from the reaction of nitrosoarenes with arylsubstituted acetylenes under reductive conditions using sodium borohydride. Terminal alkynes reacted better than non-terminal ones with various substituted...

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Bibliographic Details
Published in:ACS catalysis 2011-01, Vol.1 (1), p.29-31
Main Authors: Murru, Siva, Gallo, August A, Srivastava, Radhey S
Format: Article
Language:English
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Summary:We have successfully developed a Au-catalyzed annulation method to produce substituted 3-arylindoles from the reaction of nitrosoarenes with arylsubstituted acetylenes under reductive conditions using sodium borohydride. Terminal alkynes reacted better than non-terminal ones with various substituted nitrosoarenes to afford regioselective 3-substituted indoles. This method is simple and straightforward and can be applied successfully to the synthesis of highly substituted indoles.
ISSN:2155-5435
2155-5435
DOI:10.1021/cs100024n