Asymmetric Catalysis for the Synthesis of Spirocyclic Compounds

Spirocycles provide an exciting platform to develop and understand the reactivity and selectivity for a wide variety of catalysts while affording diverse strategies to access molecules with important applications. This review features recent examples in which a spirocenter is formed within the key s...

Full description

Saved in:
Bibliographic Details
Published in:ACS catalysis 2013-04, Vol.3 (4), p.540-553
Main Authors: Franz, Annaliese K, Hanhan, Nadine V, Ball-Jones, Nicolas R
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Spirocycles provide an exciting platform to develop and understand the reactivity and selectivity for a wide variety of catalysts while affording diverse strategies to access molecules with important applications. This review features recent examples in which a spirocenter is formed within the key step of a catalytic asymmetric process, in either an intramolecular or intermolecular fashion. Examples highlight notable spirocyclization strategies and compare the reactivity and selectivity for different classes of chiral organocatalysts and organometallic catalysts.
ISSN:2155-5435
2155-5435
DOI:10.1021/cs300801y