Vanadium Complex of 2-(2‘-Pyridyl)-4,5-dicyanoimidazole Showing Spermicidal and Cytotoxic Properties

Two complexes having the formulas VO(DCIPy)2(H2O)·1.5H2O and VO(DCIPy)2(H2O)·2MeOH have been synthesized and characterized (DCIPy = 2-(2‘-pyridyl)-4,5-dicyanoimidazolato). The methanol solvated species has been studied by X-ray diffraction, and single crystals form in the space group P2(1)/n. The hy...

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Bibliographic Details
Published in:Inorganic chemistry 2006-09, Vol.45 (18), p.7105-7110
Main Authors: Less, Gregory B, Ockwig, Nathan W, Rasmussen, Paul G, Smith, Gary D, Keller, Laura M, Drach, John C
Format: Article
Language:English
Subjects:
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Cell Line, Tumor
Cell Proliferation - drug effects
Crystallography, X-Ray
Fibroblasts - drug effects
Humans
Imidazoles - chemistry
Male
Microbial Sensitivity Tests
Models, Molecular
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Sperm Motility - drug effects
Spermatocidal Agents - chemistry
Spermatocidal Agents - pharmacology
Spermatozoa - drug effects
Structure-Activity Relationship
Time Factors
Vanadium - chemistry
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Summary:Two complexes having the formulas VO(DCIPy)2(H2O)·1.5H2O and VO(DCIPy)2(H2O)·2MeOH have been synthesized and characterized (DCIPy = 2-(2‘-pyridyl)-4,5-dicyanoimidazolato). The methanol solvated species has been studied by X-ray diffraction, and single crystals form in the space group P2(1)/n. The hydrated species was studied by electron paramagnetic resonance spectroscopy in both the solid state and in a frozen solution, and the values of A ∥ examined using the additivity relationship. The hydrated species was shown to exhibit both spermicidal and cytoxic properties.
ISSN:0020-1669
1520-510X
DOI:10.1021/ic060545f