Micelle-Mediated Transport of a Sparingly Soluble Drug through Nanoporous Membranes

Micelle-mediated solute transport through nanoporous membranes can considerably increase total solute transport compared to free diffusion of solute alone. Micelle-mediated solute transport is of importance in chemical modification of porous media and controlled-release applications when the solute...

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Bibliographic Details
Published in:Industrial & engineering chemistry research 2007-09, Vol.46 (19), p.6118-6125
Main Authors: Bhown, Abhoyjit S, Stroeve, Pieter
Format: Article
Language:English
Subjects:
Applied sciences
Chemical engineering
Exact sciences and technology
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Summary:Micelle-mediated solute transport through nanoporous membranes can considerably increase total solute transport compared to free diffusion of solute alone. Micelle-mediated solute transport is of importance in chemical modification of porous media and controlled-release applications when the solute is sparingly soluble in water. Experimental and theoretical results are given for the transport of a local anesthetic, n-butyl-p-aminobenzoate, dissolved in a micellar solution of iso-octylphenoxypolyethoxyethanol through nanoporous polypropylene membranes. The membranes have slit-like pores with a characteristic dimension of 40 nm. The theory, based on the phase-separation model, is in good agreement with the experimental results on micelle-mediated transport of the anesthetic through the nanoporous membranes. Hindered diffusion of micelles inside the slit-like pores is taken into account in the theory since the micelles are spherical with a diameter of 9.28 nm.
ISSN:0888-5885
1520-5045
DOI:10.1021/ie0609665