Micronization of p-Aminosalicylic Acid Particles Using High-Gravity Technique

An antisolvent precipitation process was adopted in this study to prepare micrometer-sized p-aminosalicylic acid (PAS) particles using the high-gravity technique. The effects of operating variables on the particle size were investigated. With an increase in the dispersant concentration and disk diam...

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Bibliographic Details
Published in:Industrial & engineering chemistry research 2010-09, Vol.49 (18), p.8832-8840
Main Authors: Chen, Yu-Shao, Wang, Yao-Hsuan, Liu, Hwai-Shen, Hsu, Kuang-Yang, Tai, Clifford Y
Format: Article
Language:English
Subjects:
Applied sciences
Chemical engineering
Exact sciences and technology
General Research
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Summary:An antisolvent precipitation process was adopted in this study to prepare micrometer-sized p-aminosalicylic acid (PAS) particles using the high-gravity technique. The effects of operating variables on the particle size were investigated. With an increase in the dispersant concentration and disk diameter or a decrease in the drug (PAS) concentration, the particle size of PAS was reduced. In addition, a circular-tube distributor was more effective than a straight-tube distributor for micronization. On the other hand, the effect of the liquid flow rate in the range between 0.25 and 1 L/min was less significant. The high-pressure homogenization following the high-gravity precipitation would effectively reduce the agglomeration of the particles in the suspension to produce drug particles with a mean size of 1 μm. The enhancement of the dissolution rate was significant for the micronized drug particles. The results indicate that the high-gravity process is a promising approach for micronizing drug particles.
ISSN:0888-5885
1520-5045
DOI:10.1021/ie1007932