Active Cytotoxic Reagents Based on Non-metallocene Non-diketonato Well-Defined C 2-Symmetrical Titanium Complexes of Tetradentate Bis(phenolato) Ligands

A new family of non-Cp-based non-diketonato-based C 2-symmetrical octahedral Ti(IV) complexes of dianionic diamine bis(phenolato) ligands, which are conveniently obtained as single isomers in quantitative yields, leads to appreciable cytotoxicity against colon and ovarian cells with a non-transferri...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2007-10, Vol.129 (40), p.12098-12099
Main Authors: Shavit, Michal, Peri, Dani, Manna, Cesar M, Alexander, Jacob S, Tshuva, Edit Y
Format: Article
Language:English
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Summary:A new family of non-Cp-based non-diketonato-based C 2-symmetrical octahedral Ti(IV) complexes of dianionic diamine bis(phenolato) ligands, which are conveniently obtained as single isomers in quantitative yields, leads to appreciable cytotoxicity against colon and ovarian cells with a non-transferrin-dependent cell penetration mechanism. The ligand structural features including steric demands, symmetry, and aromaticity strongly influence activity, supporting its role in the biological mechanism of action.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja0753086