68 Ga-NODAGA-Indole: An Allysine-Reactive Positron Emission Tomography Probe for Molecular Imaging of Pulmonary Fibrogenesis

Oxidized collagen, wherein lysine residues are converted to the aldehyde allysine, is a universal feature of fibrogenesis, i.e. actively progressive fibrosis. Here we report the small molecule, allysine-binding positron emission tomography probe, Ga-NODAGA-indole, that can noninvasively detect and q...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2019-04, Vol.141 (14), p.5593-5596
Main Authors: Wahsner, Jessica, Désogère, Pauline, Abston, Eric, Graham-O'Regan, Katherine A, Wang, Junfeng, Rotile, Nicholas J, Schirmer, Markus D, Santos Ferreira, Diêgo Dos, Sui, Jingyi, Fuchs, Bryan C, Lanuti, Michael, Caravan, Peter
Format: Article
Language:English
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Summary:Oxidized collagen, wherein lysine residues are converted to the aldehyde allysine, is a universal feature of fibrogenesis, i.e. actively progressive fibrosis. Here we report the small molecule, allysine-binding positron emission tomography probe, Ga-NODAGA-indole, that can noninvasively detect and quantify pulmonary fibrogenesis. We demonstrate that the uptake of Ga-NODAGA-indole in actively fibrotic lungs is 7-fold higher than in control groups and that uptake is linearly correlated ( R = 0.98) with the concentration of lung allysine.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.8b12342