Solubility of Paracetamol in Pure Solvents

The solubility of paracetamol (4-hydroxyacetanilide) in 26 solvents in the temperature range from −5 to +30 °C is reported. Paracetamol has a very low solubility in nonpolar and chlorinated hydrocarbons such as toluene and carbon tetrachloride whereas the solubility is very high in solvents of mediu...

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Bibliographic Details
Published in:Journal of chemical and engineering data 1999-11, Vol.44 (6), p.1391-1395
Main Authors: Granberg, Roger A, Rasmuson, Åke C
Format: Article
Language:English
Subjects:
Biological and medical sciences
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
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Summary:The solubility of paracetamol (4-hydroxyacetanilide) in 26 solvents in the temperature range from −5 to +30 °C is reported. Paracetamol has a very low solubility in nonpolar and chlorinated hydrocarbons such as toluene and carbon tetrachloride whereas the solubility is very high in solvents of medium polarity such as N,N-dimethylformamide, dimethyl sulfoxide, and diethylamine. Paracetamol is soluble in alcohols, but the solubility decreases with an increase in the length of the carbon chain in the n-alcohol homologous series (methanol to 1-octanol). The solubility of paracetamol in water is much lower than in other polar solvents such as the alcohols. The ideal solubility of paracetamol is calculated, and the activity coefficient in the saturated solutions is estimated.
ISSN:0021-9568
1520-5134
DOI:10.1021/je990124v