Effect of high dietary nitrate on the disposition of sulfamethazine [4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide] in swine

Swine (58-74-kg initial weight) were fed a corn-soybean meal basal diet that contained 110 ppm sulfamethazine [4-amino-N(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide; sulmet] and 0, 10, 100, 500, or 1000 ppm nitrate. The concentrations of nitrite in the oral cavity and the concentrations of desamin...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 1990-01, Vol.38 (1), p.308-310
Main Authors: Paulson, Gaylord D, Aschbacher, Peter W
Format: Article
Language:English
Subjects:
additif aux aliments des animaux
aditivos de piensos
animal tissues
Biological and medical sciences
cerdo
diet
dieta
feed additives
Feed and pet food industries
Food industries
Fundamental and applied biological sciences. Psychology
nitrate
nitrates
nitratos
porcin
regime alimentaire
sulfamide
sulfonamidas
sulphonamides
swine
tejidos animales
tissu animal
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Summary:Swine (58-74-kg initial weight) were fed a corn-soybean meal basal diet that contained 110 ppm sulfamethazine [4-amino-N(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide; sulmet] and 0, 10, 100, 500, or 1000 ppm nitrate. The concentrations of nitrite in the oral cavity and the concentrations of desaminosulfamethazine [N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide, DA-sulmet] in the blood were increased by feeding the highest levels of nitrate; however, 10 or 100 ppm of nitrate in the diet had little or no effect on nitrite and DA-sulmet concentrations in the oral cavity. Supplementing the diet with all levels of nitrate had little or no effect on the concentrations of sulmet and N4-Ac-sulmet in swine blood.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf00091a067