Nematicidal Activity of Natural Ester Compounds and Their Analogues against Pine Wood Nematode, Bursaphelenchus xylophilus

In this study, we evaluated the nematicidal activity of natural ester compounds against the pine wood nematode, Bursaphelenchus xylophilus, to identify candidates for the development of novel, safe nematicides. We also tested the nematicidal activity of synthesized analogues of these ester compounds...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2014-09, Vol.62 (37), p.9103-9108
Main Authors: Seo, Seon-Mi, Kim, Junheon, Koh, Sang-Hyun, Ahn, Young-Joon, Park, Il-Kwon
Format: Article
Language:English
Subjects:
Animals
Antinematodal Agents - pharmacology
Bursaphelenchus xylophilus
Butanols
Butyrates - pharmacology
Crotonates
Esters - pharmacology
lethal concentration 50
nematicidal properties
nematicides
nematode control
Structure-Activity Relationship
structure-activity relationships
Tylenchida - drug effects
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Summary:In this study, we evaluated the nematicidal activity of natural ester compounds against the pine wood nematode, Bursaphelenchus xylophilus, to identify candidates for the development of novel, safe nematicides. We also tested the nematicidal activity of synthesized analogues of these ester compounds to determine the structure–activity relationship. Among 28 ester compounds tested, isobutyl 2-methylbutanoate, 3-methylbutyl 2-methylbutanoate, 3-methylbutyl tiglate, 3-methyl-2-butenyl 2-methylbutanoate, and pentyl 2-methylbutanoate showed strong nematicidal activity against the pine wood nematode at a 1 mg/mL concentration. The other ester compounds showed weak nematicidal activity. The LC50 values of 3-methylbutyl tiglate, isobutyl 2-methylbutanoate, 3-methylbutyl 2-methylbutanoate, 3-methyl-2-butenyl 2-methylbutanoate, and pentyl 2-methylbutanoate were 0.0218, 0.0284, 0.0326, 0.0402, and 0.0480 mg/mL, respectively. The ester compounds described herein merit further study as potential nematicides for pine wood nematode control.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf503631e