Oxidative Stress and DNA Damage Induced by Imidacloprid in Zebrafish (Danio rerio)

Imidacloprid is a neonicotinoid insecticide that can have negative effects on nontarget animals. The present study was conducted to assess the toxicity of various imidacloprid doses (0.3, 1.25, and 5 mg/mL) on zebrafish sampled after 7, 14, 21, and 28 days of exposure. The levels of catalase (CAT),...

Full description

Saved in:
Bibliographic Details
Published in:Journal of agricultural and food chemistry 2015-02, Vol.63 (6), p.1856-1862
Main Authors: Ge, Weili, Yan, Saihong, Wang, Jinhua, Zhu, Lusheng, Chen, Aimei, Wang, Jun
Format: Article
Language:English
Subjects:
adverse effects
Animals
catalase
Catalase - analysis
Danio rerio
DNA damage
DNA Damage - drug effects
Dose-Response Relationship, Drug
exposure duration
Female
glutathione transferase
Glutathione Transferase - analysis
imidacloprid
Imidazoles - administration & dosage
Imidazoles - toxicity
Insecticides
Liver - chemistry
Liver - enzymology
Male
malondialdehyde
Malondialdehyde - analysis
Neonicotinoids
Nitro Compounds - administration & dosage
Nitro Compounds - toxicity
oxidative stress
Oxidative Stress - drug effects
reactive oxygen species
Reactive Oxygen Species - metabolism
superoxide dismutase
Superoxide Dismutase - analysis
toxicity
Zebrafish
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Imidacloprid is a neonicotinoid insecticide that can have negative effects on nontarget animals. The present study was conducted to assess the toxicity of various imidacloprid doses (0.3, 1.25, and 5 mg/mL) on zebrafish sampled after 7, 14, 21, and 28 days of exposure. The levels of catalase (CAT), superoxide dismutase (SOD), reactive oxygen species (ROS), glutathione-S-transferase (GST), and malondialdehyde (MDA) and the extent of DNA damage were measured to evaluate the toxicity of imidacloprid on zebrafish. SOD and GST activities were noticeably increased during early exposure but were inhibited toward the end of the exposure period. In addition, the CAT levels decreased to the control level following their elevation during early exposure. High concentrations of imidacloprid (1.25 and 5 mg/L) induced excessive ROS production and markedly increased MDA content on the 21st day of exposure. DNA damage was dose- and time-dependent. In conclusion, the present study showed that imidacloprid can induce oxidative stress and DNA damage in zebrafish.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf504895h