Ovine Metabolism of Zearalenone to α-Zearalanol (Zeranol)

This is the first report of a metabolic conversion in animals of zearalenone to zearalanols. Zearalenone was labeled with deuterium by base-catalyzed isotope exchange. The labeled zearalenone, in the form of its β-cyclodextrin inclusion complex, was administered orally and intravenously to sheep. In...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 1996-10, Vol.44 (10), p.3244-3250
Main Authors: Miles, Christopher O, Erasmuson, Anton F, Wilkins, Alistair L, Towers, Neale R, Smith, Barry L, Garthwaite, Ian, Scahill, Bryan G, Hansen, Richard P
Format: Article
Language:English
Subjects:
Biological and medical sciences
BIOTRANSFORMATION
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
METABOLISM
METABOLISME
METABOLISMO
METABOLITE
METABOLITES
METABOLITOS
OVIN
OVINOS
SHEEP
Vertebrates: anatomy and physiology, studies on body, several organs or systems
ZEARALENOL
ZERANOL
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Summary:This is the first report of a metabolic conversion in animals of zearalenone to zearalanols. Zearalenone was labeled with deuterium by base-catalyzed isotope exchange. The labeled zearalenone, in the form of its β-cyclodextrin inclusion complex, was administered orally and intravenously to sheep. In addition to deuteriozearalenone glucuronide, analysis of the urine revealed the presence of deuteriated α- and β-zearalenol and α- and β-zearalanol glucuronides. No zearalanone was detected in the urine. The problem of cis−trans isomerization of zearalenone in the presence of sunlight is also discussed. Keywords: Zeranol; zearalanol; zearalenone; zearalenol; metabolism; residue; Fusarium; mycotoxin
ISSN:0021-8561
1520-5118
DOI:10.1021/jf9601325