Teratogenic Effects of Fusaproliferin on Chicken Embryos

Fusaproliferin (FP) is a sesterterpene mycotoxin produced by some species of Fusarium, common contaminants of maize. Toxicity assays on Artemia salina L. brine shrimp larvae using FP and its derivatives showed that toxic activity of the metabolite increased after acetylation of the two hydroxyl grou...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 1997-08, Vol.45 (8), p.3039-3043
Main Authors: Ritieni, Alberto, Monti, Simona Maria, Randazzo, Giacomino, Logrieco, Antonio, Moretti, Antonio, Peluso, Giuseppe, Ferracane, Rosalia, Fogliano, Vincenzo
Format: Article
Language:English
Subjects:
ARTEMIA SALINA
Biological and medical sciences
Food industries
Food toxicology
Fundamental and applied biological sciences. Psychology
FUSARIUM
MAIS
MAIZ
MAIZE
Medical sciences
MICOTOXINAS
MYCOTOXINE
MYCOTOXINS
TOXICIDAD
TOXICITE
TOXICITY
Toxicology
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Summary:Fusaproliferin (FP) is a sesterterpene mycotoxin produced by some species of Fusarium, common contaminants of maize. Toxicity assays on Artemia salina L. brine shrimp larvae using FP and its derivatives showed that toxic activity of the metabolite increased after acetylation of the two hydroxyl groups and was reduced when the naturally occurring acetyl group was removed. In chick embryotoxicity bioassays, severe teratogenic effects were observed in 20% of the embryos exposed at 5 mM FP on day 1. In particular FP was responsible for cephalic dicotomy, macrocephaly, and limb asymmetry. At the same concentration, FP also caused pathological changes such as hemorrhaging on the surface of the wings, skull, and legs. Incomplete closure of the umbilicus was seen in 30% of embryos inoculated with 5 mM of FP on day 1 and in 20% of those inoculated on day 11. Keywords: Fusaproliferin; Fusarium proliferatum; chick; embryotoxicity; teratogenic; mycotoxin
ISSN:0021-8561
1520-5118
DOI:10.1021/jf960890v