Determination of Bisphenol-A in Reusable Polycarbonate Food-Contact Plastics and Migration to Food-Simulating Liquids

• Published in: Journal of agricultural and food chemistry 1997-09, Vol.45 (9), p.3541-3544
• Main Authors: Biles, J. E, McNeal, T. P, Begley, T. H, Hollifield, H. C
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; food composition; Food industries; food packaging; food quality; Fundamental and applied biological sciences. Psychology; General aspects; Handling, storage, packaging, transport
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf970072i

Bisphenol-A (BPA) is a principal reactant in the preparation of polycarbonate (PC) plastics and has been shown in in vitro cell proliferation studies to exhibit estrogen-like characteristics. Reusable baby bottles, water carboys, and other housewares are often made of PC. A high-pressure liquid chromatographic (HPLC) protocol was used to determine residual BPA in PC and BPA migrated to food simulants in contact with PC under controlled time/temperature conditions. Confirmation of BPA was performed by gas chromatography/mass spectrometry (GC−MS). Residual amounts of BPA found in PC food contact articles ranged from 7 to 58 μg/g. In migration tests the plastic was exposed to water, ethanol/water mixtures, and Miglyol (a food oil simulant) in sealed vials at a constant temperature of 65 °C, for up to 10 days. BPA in food simulants ranged from 13 to 368% of BPA available to migrate from the polymer. GC−MS methods were applied to the analysis of water stored in reusable PC 5-gal water carboys. The amount of BPA found in the water ranged from ND to 5 ppb. Keywords: Bisphenol-A; polycarbonate; migration; baby bottles; hydrolysis