Phencyclidine-like effects of tetrahydroisoquinolines and related compounds

A series of 1,2,3,4-tetrahydroisoquinolines, tetrahydrothieno[2,3-c]pyridines, and related compounds were evaluated for their ability to inhibit binding of [3H]-1-[1-(2-thienyl)piperidine and [3H]-N-allylnormetazocine to phencyclidine (PCP) and sigma receptors, respectively. A representative series...

Full description

Saved in:
Bibliographic Details
Published in:Journal of medicinal chemistry 1989-06, Vol.32 (6), p.1242-1248
Main Authors: Gray, Nancy M, Cheng, Brian K, Mick, Stephen J, Lair, Cecelia M, Contreras, Patricia C
Format: Article
Language:English
Subjects:
Animals
Ataxia - chemically induced
Behavior, Animal - drug effects
Chemical Phenomena
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Isoquinolines - chemical synthesis
Isoquinolines - metabolism
Isoquinolines - pharmacology
Male
Molecular Structure
Organic chemistry
Phenazocine - analogs & derivatives
Phenazocine - metabolism
Phencyclidine - analogs & derivatives
Phencyclidine - metabolism
Phencyclidine - pharmacology
Preparations and properties
Rats
Rats, Inbred Strains
Receptors, Neurotransmitter - metabolism
Receptors, Phencyclidine
Stereotyped Behavior - drug effects
Structure-Activity Relationship
Tetrahydroisoquinolines
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of 1,2,3,4-tetrahydroisoquinolines, tetrahydrothieno[2,3-c]pyridines, and related compounds were evaluated for their ability to inhibit binding of [3H]-1-[1-(2-thienyl)piperidine and [3H]-N-allylnormetazocine to phencyclidine (PCP) and sigma receptors, respectively. A representative series of compounds was evaluated in behavioral assays to determine the ability of the compounds to induce PCP-like stereotyped behavior and ataxia. All of the compounds caused stereotyped behavior and ataxia, indicating their agonist actions at the PCP site.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00126a016