Anticonvulsants. 5. Derivatives of 5-ethyl-5-phenylhydantoin and 5,5-diphenylhydantoin

Alkoxymethyl, acyloxymethyl, and mixed alkylalkoxymethyl or alkylacyloxymethyl derivatives of 5-ethyl-5-phenylhydantoin exhibit anticonvulsant activity. Also effective are bis(alkoxymethyl) and mixed alkylalkoxymethyl derivatives of 5,5-diphenylhydantoin. Of particular interest are 1,3-bis(methoxyme...

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Bibliographic Details
Published in:Journal of medicinal chemistry 1975-04, Vol.18 (4), p.383-385
Main Authors: Vida, Julius A, O'Dea, Mary H, Samour, Carlos M, Reinhard, John F
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants - chemical synthesis
Anticonvulsants - pharmacology
Anticonvulsants - toxicity
Depression, Chemical
Electroshock
Hydantoins - chemical synthesis
Hydantoins - pharmacology
Hydantoins - toxicity
Lethal Dose 50
Male
Mice
Motor Activity - drug effects
Pentylenetetrazole - antagonists & inhibitors
Phenytoin - analogs & derivatives
Phenytoin - chemical synthesis
Phenytoin - pharmacology
Phenytoin - toxicity
Reflex - drug effects
Seizures - prevention & control
Sleep - drug effects
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Summary:Alkoxymethyl, acyloxymethyl, and mixed alkylalkoxymethyl or alkylacyloxymethyl derivatives of 5-ethyl-5-phenylhydantoin exhibit anticonvulsant activity. Also effective are bis(alkoxymethyl) and mixed alkylalkoxymethyl derivatives of 5,5-diphenylhydantoin. Of particular interest are 1,3-bis(methoxymethyl)-5,5-diphenylhydantoin and 3-acetoxymethyl-5-ethyl-5-phenylhydantoin, which show good activity against maximal electroshock seizures, and 3-methoxymethyl-5-ethyl-5-phenylhydantoin, which is effective against both maximal electroshock and pentylenetetrazole. None of the above compounds show greater activity against maximal electroshock seizures than the parent compounds, however.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00238a012