Discovery of a Brain-Penetrant S1P 3 -Sparing Direct Agonist of the S1P 1 and S1P 5 Receptors Efficacious at Low Oral Dose

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Bibliographic Details
Published in:Journal of medicinal chemistry 2011-10, Vol.54 (19), p.6724-6733
Main Authors: Demont, Emmanuel H., Arpino, Sandra, Bit, Rino A., Campbell, Colin A., Deeks, Nigel, Desai, Sapna, Dowell, Simon J., Gaskin, Pam, Gray, James R. J., Harrison, Lee A., Haynes, Andrea, Heightman, Tom D., Holmes, Duncan S., Humphreys, Philip G., Kumar, Umesh, Morse, Mary A., Osborne, Greg J., Panchal, Terry, Philpott, Karen L., Taylor, Simon, Watson, Robert, Willis, Robert, Witherington, Jason
Format: Article
Language:English
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ISSN:0022-2623
1520-4804
DOI:10.1021/jm200609t