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Multiparameter Optimization in CNS Drug Discovery: Design of Pyrimido[4,5- d ]azepines as Potent 5-Hydroxytryptamine 2C (5-HT 2C ) Receptor Agonists with Exquisite Functional Selectivity over 5-HT 2A and 5-HT 2B Receptors

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Bibliographic Details
Published in:Journal of medicinal chemistry 2014-06, Vol.57 (12), p.5258-5269
Main Authors: Storer, R. Ian, Brennan, Paul E., Brown, Alan D., Bungay, Peter J., Conlon, Kelly M., Corbett, Matthew S., DePianta, Robert P., Fish, Paul V., Heifetz, Alexander, Ho, Danny K. H., Jessiman, Alan S., McMurray, Gordon, de Oliveira, Cesar Augusto F., Roberts, Lee R., Root, James A., Shanmugasundaram, Veerabahu, Shapiro, Michael J., Skerten, Melanie, Westbrook, Dominique, Wheeler, Simon, Whitlock, Gavin A., Wright, John
Format: Article
Language:English
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ISSN:0022-2623
1520-4804
DOI:10.1021/jm5003292