Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2 S )-4-(2,5-Difluorophenyl)- N -[(3 R ,4 S )-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)- N -methyl-2-phenyl-2,5-dihydro-1 H -pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

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Bibliographic Details
Published in:Journal of medicinal chemistry 2008-07, Vol.51 (14), p.4239-4252
Main Authors: Cox, Christopher D., Coleman, Paul J., Breslin, Michael J., Whitman, David B., Garbaccio, Robert M., Fraley, Mark E., Buser, Carolyn A., Walsh, Eileen S., Hamilton, Kelly, Schaber, Michael D., Lobell, Robert B., Tao, Weikang, Davide, Joseph P., Diehl, Ronald E., Abrams, Marc T., South, Vicki J., Huber, Hans E., Torrent, Maricel, Prueksaritanont, Thomayant, Li, Chunze, Slaughter, Donald E., Mahan, Elizabeth, Fernandez-Metzler, Carmen, Yan, Youwei, Kuo, Lawrence C., Kohl, Nancy E., Hartman, George D.
Format: Article
Language:English
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ISSN:0022-2623
1520-4804
DOI:10.1021/jm800386y