Novel Conformationally Extended Naphthalene-Based Inhibitors of Farnesyltransferase

• Published in: Journal of medicinal chemistry 1997-06, Vol.40 (12), p.1763-1767
• Main Authors: Burns, Christopher J, Guitton, Jean-Dominique, Baudoin, Bernard, Lelièvre, Yves, Duchesne, Marc, Parker, Fabienne, Fromage, Nadine, Commerçon, Alain
• Format: Article
• Language: English
• Subjects: 2-Naphthylamine - analogs & derivatives; 2-Naphthylamine - chemical synthesis; 2-Naphthylamine - chemistry; 2-Naphthylamine - pharmacology; Alkyl and Aryl Transferases; Amino Acid Sequence; Antineoplastic agents; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - pharmacology; Biological and medical sciences; Cell Division - drug effects; Cell Line, Transformed; Cysteine - chemistry; Dipeptides - chemical synthesis; Dipeptides - chemistry; Dipeptides - pharmacology; Enzyme Inhibitors - chemical synthesis; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; Farnesyltranstransferase; General aspects; Genes, ras; Medical sciences; Methionine - chemistry; Models, Molecular; Molecular Structure; Naphthalenes - chemistry; Pharmacology. Drug treatments; Protein Conformation; ras Proteins - metabolism; Structure-Activity Relationship; Transferases - antagonists & inhibitors; Tumor Cells, Cultured
• ISSN: 0022-2623; 1520-4804
• DOI: 10.1021/jm9701177