Palladium-Catalyzed Cyanation of Aryl Halides with CuSCN

A palladium-catalyzed cyanation of aryl halides and borons has been developed by employing cuprous thiocyanate as a safe cyanide source. This protocol avoids the use of a highly toxic cyanide source, providing aromatic nitriles in moderate to good yields with good functional tolerance.

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Bibliographic Details
Published in:Journal of organic chemistry 2013-03, Vol.78 (6), p.2710-2714
Main Authors: Zhang, Guo-Ying, Yu, Jin-Tao, Hu, Mao-Lin, Cheng, Jiang
Format: Article
Language:English
Subjects:
Catalysis
Halogens - chemistry
Molecular Structure
Nitriles - chemical synthesis
Nitriles - chemistry
Palladium - chemistry
Thiocyanates - chemistry
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Description
Summary:A palladium-catalyzed cyanation of aryl halides and borons has been developed by employing cuprous thiocyanate as a safe cyanide source. This protocol avoids the use of a highly toxic cyanide source, providing aromatic nitriles in moderate to good yields with good functional tolerance.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo3025829