Pestalotiopsins A and B:  New Caryophyllenes from an Endophytic Fungus of Taxus brevifolia

Two new caryophyllene sesquiterpenes have been isolated from Pestalotiopsis sp., an endophytic fungus associated with the bark and leaves of Taxus brevifolia. Pestalotiopsin A (1) has a novel oxatricyclic ring system while pestalotiopsin B (3) exists as two slowly equilibrating atropisomers (6:5 rat...

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Published in:Journal of organic chemistry 1996-03, Vol.61 (6), p.2122-2124
Main Authors: Pulici, Maurizio, Sugawara, Fumio, Koshino, Hiroyuki, Uzawa, Jun, Yoshida, Shigeo, Lobkovsky, Emil, Clardy, Jon
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container_issue 6
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container_title Journal of organic chemistry
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creator Pulici, Maurizio
Sugawara, Fumio
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description Two new caryophyllene sesquiterpenes have been isolated from Pestalotiopsis sp., an endophytic fungus associated with the bark and leaves of Taxus brevifolia. Pestalotiopsin A (1) has a novel oxatricyclic ring system while pestalotiopsin B (3) exists as two slowly equilibrating atropisomers (6:5 ratio of ββ:βα) in chloroform solution at room temperature. Structures of 1 and 3 were determined by spectroscopic analyses and single-crystal X-ray diffraction.
doi_str_mv 10.1021/jo951736v
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title Pestalotiopsins A and B:  New Caryophyllenes from an Endophytic Fungus of Taxus brevifolia
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