Enantioselective Approach to Polyhydroxylated Compounds Using Chiral Sulfoxides:  Synthesis of Enantiomerically Pure myo-Inositol and Pyrrolidine Derivatives

A short enantioselective synthesis of the biologically important myo-inositol derivative I and the pyrrolidine derivative II is described. The molecule 3, a diketo disulfoxide readily made from tartaric acid, is the key intermediate. The sulfinyl group controlled completely the very high stereoselec...

Full description

Saved in:
Bibliographic Details
Published in:Journal of organic chemistry 1998-11, Vol.63 (24), p.8918-8921
Main Authors: Colobert, Françoise, Tito, Amélia, Khiar, Noureddine, Denni, Donatienne, Medina, Maria Angeles, Martin-Lomas, Manuel, Ruano, José-Luis Garcia, Solladié, Guy
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A short enantioselective synthesis of the biologically important myo-inositol derivative I and the pyrrolidine derivative II is described. The molecule 3, a diketo disulfoxide readily made from tartaric acid, is the key intermediate. The sulfinyl group controlled completely the very high stereoselection observed.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo9811569