Enhanced Oxygen Singlet Production by Hybrid System of Porphyrin and Enriched (6,5) Single-Walled Carbon Nanotubes for Photodynamic Therapy

We demonstrate that hybrid systems of porphyrins and chirality enriched (6,5) single-walled carbon nanotubes (E-SWCNTs) are better candidates for photodynamic therapy (PDT) than their components alone. Surprisingly, the E-SWCNTs act as optical absorption enhancers to the porphyrins increasing the ox...

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Bibliographic Details
Published in:Journal of physical chemistry. C 2015-02, Vol.119 (8), p.4344-4350
Main Authors: Sáfar, Gustavo A. M, Gontijo, Rafael N, Fantini, Cristiano, Martins, Dayse C. S, Idemori, Ynara M, Pinheiro, Maurício V. B, Krambrock, Klaus
Format: Article
Language:English
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Summary:We demonstrate that hybrid systems of porphyrins and chirality enriched (6,5) single-walled carbon nanotubes (E-SWCNTs) are better candidates for photodynamic therapy (PDT) than their components alone. Surprisingly, the E-SWCNTs act as optical absorption enhancers to the porphyrins increasing the oxygen singlet production when illuminated by a light source with energy higher than the E-SWCNT gap plus the equivalent in energy of an E-SWCNT phonon. The phenomenon is explained based on energy transfer from the E-SWCNT to the porphyrin which finally transfers it to the oxygen molecule. The large optical absorption cross section of E-SWCNT and the resonance of the porphyrin to the oxygen singlet–triplet transition are responsible for the synergistic effect.
ISSN:1932-7447
1932-7455
DOI:10.1021/jp5111289