SANS Study of the Structural Phases of Magnetically Alignable Lanthanide-Doped Phospholipid Mixtures

The structural phases of magnetically alignable lipid mixtures were investigated as a function of temperature and lipid concentration using small-angle neutron scattering (SANS). Two systems were examined:  (a) an aqueous mixture of DMPC (dimyristoyl phosphatidylcholine) and DHPC (dihexanoyl phospha...

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Published in:Langmuir 2001-05, Vol.17 (9), p.2629-2638
Main Authors: Nieh, Mu-Ping, Glinka, Charles J, Krueger, Susan, Prosser, R. Scott, Katsaras, John
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description The structural phases of magnetically alignable lipid mixtures were investigated as a function of temperature and lipid concentration using small-angle neutron scattering (SANS). Two systems were examined:  (a) an aqueous mixture of DMPC (dimyristoyl phosphatidylcholine) and DHPC (dihexanoyl phosphatidylcholine) lipids doped with Tm3+ ions resulting in the positive alignment of the system with the applied magnetic field and (b) the above aqueous Tm3+ doped lipid mixture containing a negatively charged lipid, DMPG (dimyristoylphosphatidylglycerol). For both systems, three different scattering patterns were observed corresponding to distinct structural phases at specific temperatures and lipid concentrations. At 45 °C and a lipid concentration of >0.05 g/mL, the high-viscosity liquid crystalline phase was found to be a perforated and possibly undulating lamellar phase consistent with NMR results. Upon dilution (
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title SANS Study of the Structural Phases of Magnetically Alignable Lanthanide-Doped Phospholipid Mixtures
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