Rapid Gel Formation and Adhesion in Photocurable and Biodegradable Block Copolymers with High DOPA Content

Marine mussels anchor to a variety of surfaces in turbulent intertidal zones through the use of adhesive plaques formed from hardened mussel adhesive proteins (MAPs). It is believed that 3,4-dihydroxyphenylalanine (DOPA) imparts both water-resistant adhesive characteristics and rapid curing ability...

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Bibliographic Details
Published in:Macromolecules 2006-03, Vol.39 (5), p.1740-1748
Main Authors: Lee, Bruce P, Chao, Chi-Yang, Nunalee, F. Nelson, Motan, Emre, Shull, Kenneth R, Messersmith, Phillip B
Format: Article
Language:English
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Summary:Marine mussels anchor to a variety of surfaces in turbulent intertidal zones through the use of adhesive plaques formed from hardened mussel adhesive proteins (MAPs). It is believed that 3,4-dihydroxyphenylalanine (DOPA) imparts both water-resistant adhesive characteristics and rapid curing ability to MAPs. In this paper, DOPA-modified triblock copolymers were synthesized and used to form adhesive hydrogels. Amphiphilic block copolymers with DOPA content as high as 10 wt % were prepared, and aqueous solutions of the polymers rapidly (
ISSN:0024-9297
1520-5835
DOI:10.1021/ma0518959