Versatile Copolymerization of Glycolide and rac-Lactide by Dimethyl(salicylaldiminato)aluminum Compounds

The dimethylaluminum compounds Al(CH3)2[(O-2-{(C6F5)NCH}-4,6-R2C6H2)], R = H (1) or cumyl (2), were synthesized and tested as initiators in the homo- and copolymerization of rac-lactide and glycolide. These complexes resulted active for the production of PLGA copolymers with variable microstructure...

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Bibliographic Details
Published in:Macromolecules 2014-01, Vol.47 (2), p.534-543
Main Authors: Meduri, Angelo, Fuoco, Tiziana, Lamberti, Marina, Pellecchia, Claudio, Pappalardo, Daniela
Format: Article
Language:English
Subjects:
Applied sciences
Copolymerization
Exact sciences and technology
Organic polymers
Physicochemistry of polymers
Preparation, kinetics, thermodynamics, mechanism and catalysts
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Summary:The dimethylaluminum compounds Al(CH3)2[(O-2-{(C6F5)NCH}-4,6-R2C6H2)], R = H (1) or cumyl (2), were synthesized and tested as initiators in the homo- and copolymerization of rac-lactide and glycolide. These complexes resulted active for the production of PLGA copolymers with variable microstructure. All the copolymers were fully characterized by NMR, GPC, and DSC analysis. The copolymerization reactions were performed in bulk and in solution, by varying comonomers ratio, monomer/catalyst feed ratio, temperature, reaction time, and solvent. Interestingly, by changing the reaction conditions, copolymers from random, to blocky, to diblock were obtained, demonstrating the effectiveness and versatility of such systems in modulating the copolymers microstructure and the related thermal properties.
ISSN:0024-9297
1520-5835
DOI:10.1021/ma402174y