Water-Soluble Porous Nanospheres

Poly[(2-cinnamoylethyl methacrylate)-random-(2-octanoylethyl methacrylate)]-block-poly(acrylic acid) [P(CEMA-r-OEMA)-b-PAA] forms micelles in water with P(CEMA-r-OEMA) as the core and PAA as the shell. POEMA is incorporated into the micellar cores. After PCEMA cross-linking, POEMA is extracted to pr...

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Bibliographic Details
Published in:Macromolecules 1998-06, Vol.31 (13), p.4213-4217
Main Authors: Henselwood, Fred, Liu, Guojun
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Crosslinking and degradation
Exact sciences and technology
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Polymers and radiations
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Summary:Poly[(2-cinnamoylethyl methacrylate)-random-(2-octanoylethyl methacrylate)]-block-poly(acrylic acid) [P(CEMA-r-OEMA)-b-PAA] forms micelles in water with P(CEMA-r-OEMA) as the core and PAA as the shell. POEMA is incorporated into the micellar cores. After PCEMA cross-linking, POEMA is extracted to produce porous water-soluble P(CEMA-r-OEMA)-b-PAA nanospheres. The porous nanospheres sorb a significantly higher amount of perylene from water/acetone and water/acetone/DMSO mixtures than the nonporous P(CEMA-r-OEMA)-b-PAA nanospheres.
ISSN:0024-9297
1520-5835
DOI:10.1021/ma9802327