Cytotoxicity of Colloidal CdSe and CdSe/ZnS Nanoparticles

Cytotoxicity of CdSe and CdSe/ZnS nanoparticles has been investigated for different surface modifications such as coating with mercaptopropionic acid, silanization, and polymer coating. For all cases, quantitative values for the onset of cytotoxic effects in serum-free culture media are given. These...

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Bibliographic Details
Published in:Nano letters 2005-02, Vol.5 (2), p.331-338
Main Authors: Kirchner, Christian, Liedl, Tim, Kudera, Stefan, Pellegrino, Teresa, Muñoz Javier, Almudena, Gaub, Hermann E, Stölzle, Sonja, Fertig, N, Parak, Wolfgang J
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - adverse effects
Biocompatible Materials - pharmacokinetics
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cadmium Compounds - adverse effects
Cadmium Compounds - pharmacokinetics
Cell Adhesion - drug effects
Cell Line
Cell Survival - drug effects
CHO Cells
Colloids - adverse effects
Colloids - pharmacokinetics
Cricetinae
Cricetulus
Dose-Response Relationship, Drug
Fibroblasts - drug effects
Fibroblasts - metabolism
Fibroblasts - pathology
Materials Testing
Nanotubes - adverse effects
Risk Assessment - methods
Risk Factors
Selenium Compounds - adverse effects
Selenium Compounds - pharmacokinetics
Sulfides - adverse effects
Sulfides - pharmacokinetics
Zinc Compounds - adverse effects
Zinc Compounds - pharmacokinetics
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Summary:Cytotoxicity of CdSe and CdSe/ZnS nanoparticles has been investigated for different surface modifications such as coating with mercaptopropionic acid, silanization, and polymer coating. For all cases, quantitative values for the onset of cytotoxic effects in serum-free culture media are given. These values are correlated with microscope images in which the uptake of the particles by the cells has been investigated. Our data suggest that in addition to the release of toxic Cd2+ ions from the particles also their surface chemistry, in particular their stability toward aggregation, plays an important role for cytotoxic effects. Additional patch clamp experiments investigate effects of the particles on currents through ion channels.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl047996m