A Highly Effective, Nontoxic T 1 MR Contrast Agent Based on Ultrasmall PEGylated Iron Oxide Nanoparticles

In this study we systematically developed a potential MR T 1 contrast agent based on very small PEGylated iron oxide nanoparticles. We adjusted the size of the crystalline core providing suitable relaxometric properties. In addition, a dense and optimized PEG coating provides high stability under ph...

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Bibliographic Details
Published in:Nano letters 2009-12, Vol.9 (12), p.4434-4440
Main Authors: Tromsdorf, Ulrich I, Bruns, Oliver T, Salmen, Sunhild C, Beisiegel, Ulrike, Weller, Horst
Format: Article
Language:English
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Summary:In this study we systematically developed a potential MR T 1 contrast agent based on very small PEGylated iron oxide nanoparticles. We adjusted the size of the crystalline core providing suitable relaxometric properties. In addition, a dense and optimized PEG coating provides high stability under physiological conditions together with low cytotoxicity and low nonspecific phagocytosis into macrophage cells as a part of the reticulo endothelial system at biologically relevant concentrations. The as developed contrast agent has the lowest r 2/r 1 ratio (2.4) at 1.41 T reported so far for PEGylated iron oxide nanoparticles as well as a r 1 relaxivity (7.3 mM−1 s−1) that is two times higher compared to that of Magnevist as a typical T 1 contrast agent based on gadolinium as a clinical standard.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl902715v