Nanoscale Resolution, Multicomponent Biomolecular Arrays Generated By Aligned Printing With Parylene Peel-Off

We present “Print-and-Peel”, a high-throughput method to generate multicomponent biomolecular arrays with sub-100 nm nanoscale feature width. An inkjet printer is first aligned to a parylene template containing nanoscale openings. After printing, the parylene is peeled off to reveal uniformly patter...

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Bibliographic Details
Published in:Nano letters 2010-02, Vol.10 (2), p.719-725
Main Authors: Tan, Christine P, Cipriany, Benjamin R, Lin, David M, Craighead, Harold G
Format: Article
Language:English
Subjects:
Adsorption
Biotechnology - instrumentation
Biotechnology - methods
Chemical synthesis methods
Condensed matter: structure, mechanical and thermal properties
Cross-disciplinary physics: materials science
rheology
Exact sciences and technology
Fibronectins - chemistry
Humans
Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties
Materials science
Materials Testing
Methods of nanofabrication
Microarray Analysis - instrumentation
Microarray Analysis - methods
Microscopy, Atomic Force - methods
Microscopy, Fluorescence - methods
Nanocomposites - chemistry
Nanostructures
Nanotechnology - instrumentation
Nanotechnology - methods
Physics
Polymers - chemistry
Surfaces and interfaces
thin films and whiskers (structure and nonelectronic properties)
Xylenes - chemistry
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Description
Summary:We present “Print-and-Peel”, a high-throughput method to generate multicomponent biomolecular arrays with sub-100 nm nanoscale feature width. An inkjet printer is first aligned to a parylene template containing nanoscale openings. After printing, the parylene is peeled off to reveal uniformly patterned nanoscale features, despite the imperfect morphologies of the original inkjet spots. We further patterned combinatorial nanoarrays by performing a second print-run superimposed over the first, thereby extending the multiplexing capability of the technique.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl903968s