Vertilecanins:  New Phenopicolinic Acid Analogues from Verticillium l ecanii

Five new phenopicolinic acid analogues (1−5) have been isolated from solid-substrate fermentation cultures of Verticillium lecanii. The most abundant component (vertilecanin A; 1) displays antiinsectan activity against Helicoverpa zea. These compounds were obtained by chromatographic fractionation o...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2001-02, Vol.64 (2), p.189-192
Main Authors: Soman, Ashish G, Gloer, James B, Angawi, Rihab F, Wicklow, Donald T, Dowd, Patrick F
Format: Article
Language:English
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Summary:Five new phenopicolinic acid analogues (1−5) have been isolated from solid-substrate fermentation cultures of Verticillium lecanii. The most abundant component (vertilecanin A; 1) displays antiinsectan activity against Helicoverpa zea. These compounds were obtained by chromatographic fractionation of the EtOAc culture extract and identified by analysis of NMR and MS data. The known fungal metabolites 2-decenedioic acid and 10-hydroxy-8-decenoic acid were also isolated from these cultures.
ISSN:0163-3864
1520-6025
DOI:10.1021/np000094q