Activity-Guided Isolation of Antioxidative Constituents of Cotinus c oggygria

Six constituents (1 − 6) were isolated from EtOAc-soluble partitions of two separate collections of the whole plants of Cotinus coggygria, namely, disulfuretin {2,2‘-[1,2-bis(3,4-dihydroxyphenyl)-1,2-ethanedylidene]bis[6-hydroxy-3(2H)-benzofuranone] (1)}, sulfuretin (2), sulfurein (3), gallic acid (...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2000-12, Vol.63 (12), p.1696-1698
Main Authors: Westenburg, Hans E, Lee, Kon-Joo, Lee, Sang Kook, Fong, Harry H. S, van Breemen, Richard B, Pezzuto, John M, Kinghorn, A. Douglas
Format: Article
Language:English
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Summary:Six constituents (1 − 6) were isolated from EtOAc-soluble partitions of two separate collections of the whole plants of Cotinus coggygria, namely, disulfuretin {2,2‘-[1,2-bis(3,4-dihydroxyphenyl)-1,2-ethanedylidene]bis[6-hydroxy-3(2H)-benzofuranone] (1)}, sulfuretin (2), sulfurein (3), gallic acid (4), methyl gallate (5), and pentagalloyl glucose (6). The structure of the novel biaurone 1 was determined by spectral and chemical methods. Compounds 1−6 were found to be potent antioxidants in a 1,1-diphenyl-2-picrylhydrazyl free-radical scavenging assay.
ISSN:0163-3864
1520-6025
DOI:10.1021/np000292h