A Comparison of Inverse-Detected Heteronuclear NMR Performance:  Conventional vs Cryogenic Microprobe Performance

We report a comparison of the results obtained at 500 MHz for heteronuclear shift correlation (HSQC) experiments with very small natural product samples using conventional and cryogenically cooled 3 mm NMR probes. The cryo probe affords a 12- to 16-fold reduction in data acquisition time for a compa...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2000-08, Vol.63 (8), p.1047-1049
Main Authors: Russell, David J, Hadden, Chad E, Martin, Gary E, Gibson, Atholl A, Zens, Albert P, Carolan, James L
Format: Article
Language:English
Subjects:
Analytical chemistry
Atomic and molecular physics
Atomic properties and interactions with photons
Atomic spectra
Chemistry
Cold Temperature
Exact sciences and technology
Magnetic resonance spectra
Magnetic Resonance Spectroscopy - instrumentation
Magnetic Resonance Spectroscopy - methods
Physics
Poisons - chemistry
Spectrometric and optical methods
Strychnine - chemistry
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Summary:We report a comparison of the results obtained at 500 MHz for heteronuclear shift correlation (HSQC) experiments with very small natural product samples using conventional and cryogenically cooled 3 mm NMR probes. The cryo probe affords a 12- to 16-fold reduction in data acquisition time for a comparable signal-to-noise ratio.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0003140