Two New Furanoditerpenes from Saururus c hinenesis and Their Effects on the Activation of Peroxisome Proliferator-Activated Receptor γ

Two new acyclic furanoditerpene compounds, saurufuran A (1) and B (2), were obtained from the root of Saururus chinensis, and their structures were elucidated by means of 1D and 2D NMR spectroscopic analyses. Saurufuran A (1) is effective on the activation of peroxisome proliferator-activated recept...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2002-04, Vol.65 (4), p.616-617
Main Authors: Hwang, Bang Yeon, Lee, Jeong-Hyung, Nam, Jeong Bum, Kim, Hang Sub, Hong, Young Soo, Lee, Jung Joon
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two new acyclic furanoditerpene compounds, saurufuran A (1) and B (2), were obtained from the root of Saururus chinensis, and their structures were elucidated by means of 1D and 2D NMR spectroscopic analyses. Saurufuran A (1) is effective on the activation of peroxisome proliferator-activated receptor γ (PPARγ) with an EC50 value of 16.7 μM; however, saurufuran B (2), with an EC50 value of >100 μM, weakly activated the PPARγ.
ISSN:0163-3864
1520-6025
DOI:10.1021/np010440j