New Labdene Diterpenes from Eupatorium g lutinosum

The new diterpene glucoside 3,15-dihydroxy-ent-labd-7-en-17-oic acid 3-O-β-d-glucoside (1) and its aglycone (2) have been isolated from Eupatorium glutinosum. The structures were determined by IR, one- and two-dimensional NMR, high-resolution mass spectrometry, chemical transformations, and comparis...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2002-05, Vol.65 (5), p.728-729
Main Authors: El-Seedi, Hesham R, Sata, Noriko, Torssell, Kurt B. G, Nishiyama, Shigeru
Format: Article
Language:English
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Summary:The new diterpene glucoside 3,15-dihydroxy-ent-labd-7-en-17-oic acid 3-O-β-d-glucoside (1) and its aglycone (2) have been isolated from Eupatorium glutinosum. The structures were determined by IR, one- and two-dimensional NMR, high-resolution mass spectrometry, chemical transformations, and comparison of spectroscopic data with closely related diterpenes. Crude extracts showed antimicrobial and cytotoxic activities, but compounds 1 and 2 showed only antimicrobial activity. These results support the vernacular medicinal use of the plant as an antimicrobial.
ISSN:0163-3864
1520-6025
DOI:10.1021/np010595r