Antimicrobial Resveratrol Tetramers from the Stem Bark of Vatica o blongifolia ssp. o blongifolia

Two new resveratrol tetramers, hopeaphenol A (1) and isohopeaphenol A (2), along with the known vaticaphenol A (3), were isolated from the stem bark of Vatica oblongifolia ssp. oblongifolia through bioassay-guided fractionation. The structures and their relative stereochemistry were determined by sp...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2002-11, Vol.65 (11), p.1554-1559
Main Authors: Zgoda-Pols, Joanna R, Freyer, Alan J, Killmer, Lew B, Porter, John R
Format: Article
Language:English
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Summary:Two new resveratrol tetramers, hopeaphenol A (1) and isohopeaphenol A (2), along with the known vaticaphenol A (3), were isolated from the stem bark of Vatica oblongifolia ssp. oblongifolia through bioassay-guided fractionation. The structures and their relative stereochemistry were determined by spectroscopic techniques. Compounds 1 and 3 demonstrated moderate activity against methicillin-resistant Staphylococcus aureus and Mycobacterium smegmatis.
ISSN:0163-3864
1520-6025
DOI:10.1021/np020198w