Neoclerodane and Labdane Diterpenoids from Plectranthus o rnatus

Three new diterpenoids, a neoclerodane and two labdane derivatives, have been isolated from an acetone extract of Plectranthus ornatus. The structures of these compounds (plectrornatins A−C, 1−3, respectively) were established mainly by spectroscopic means, particularly by 1D and 2D NMR studies and,...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2002-10, Vol.65 (10), p.1387-1390
Main Authors: Rijo, Patrícia, Gaspar-Marques, Cristina, Simões, M. Fátima, Duarte, Aida, del Carmen Apreda-Rojas, María, Cano, Félix H, Rodríguez, Benjamín
Format: Article
Language:English
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Summary:Three new diterpenoids, a neoclerodane and two labdane derivatives, have been isolated from an acetone extract of Plectranthus ornatus. The structures of these compounds (plectrornatins A−C, 1−3, respectively) were established mainly by spectroscopic means, particularly by 1D and 2D NMR studies and, in the case of the neoclerodane 1, by an X-ray diffraction analysis. Compounds 1 and 3 showed moderate antimicrobial activity against five Candida species and selected Gram negative and Gram positive bacteria strains.
ISSN:0163-3864
1520-6025
DOI:10.1021/np020203w