Antineoplastic Agents. 529. Isolation and Structure of Nootkastatins 1 and 2 from the Alaskan Yellow Cedar Chamaecyparis n ootkatensis

The yellow cedar tree, Chamaecyparis nootkatensis, collected in southeast Alaska was evaluated as a potential source of new anticancer agents. Two new diterpene anticancer constituents termed nootkastatins 1 (4) and 2 (5) were isolated along with three previously known diterpene cancer cell growth i...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2004-09, Vol.67 (9), p.1476-1482
Main Authors: Pettit, George R, Tan, Rui, Northen, Julian S, Herald, Delbert L, Chapuis, Jean-Charles, Pettit, Robin K
Format: Article
Language:English
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Summary:The yellow cedar tree, Chamaecyparis nootkatensis, collected in southeast Alaska was evaluated as a potential source of new anticancer agents. Two new diterpene anticancer constituents termed nootkastatins 1 (4) and 2 (5) were isolated along with three previously known diterpene cancer cell growth inhibitors where two were reported as synthetic modifications of totarol and not previously found in nature. All five diterpene structures were established by HRMS and 1D and 2D NMR spectroscopic analyses combined with three X-ray crystal structure determinations (2, 3, and 5). Against a panel of six human cancer cell lines, this series of diterpenes exhibited inhibition over the range GI50 0.75−2.0 μg/mL, and all inhibited the growth of Gram-positive bacteria and fungi.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0304161