New Glycosides of the Fungus Acremonium s triatisporum Isolated from a Sea Cucumber

Four new diterpene glycosides, virescenosides R (1), S (2), T (3), and U (4), have been isolated from a marine strain of Acremonium striatisporum KMM 4401 associated with the holothurian Eupentacta fraudatrix. Their structures have been elucidated on the basis of HRFABMS, 1D and 2D NMR (1H, 13C, DEP...

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Published in:Journal of natural products (Washington, D.C.) D.C.), 2004-06, Vol.67 (6), p.1047-1051
Main Authors: Afiyatullov, Shamil Sh, Kalinovsky, Anatoly I, Kuznetsova, Tatyana A, Pivkin, Mikhail V, Prokof'eva, Nina G, Dmitrenok, Pavel S, Elyakov, George B
Format: Article
Language:English
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Summary:Four new diterpene glycosides, virescenosides R (1), S (2), T (3), and U (4), have been isolated from a marine strain of Acremonium striatisporum KMM 4401 associated with the holothurian Eupentacta fraudatrix. Their structures have been elucidated on the basis of HRFABMS, 1D and 2D NMR (1H, 13C, DEPT, COSY-45, COSY-RCT, HSQC, HMBC, and NOESY spectra), and the results of acidic hydrolysis as 19-O-{β-d-glucopyranosyl(1→6)-β-d-altropyranosyl}-isopimara-7,15-diene-2α,3β-diol (1), 19-O-β-d-altropyranosyl-3-oxo-isopimara-8(14),15-diene-7α-ol (2), 19-O-β-d-altropyranosyl-3,7-dioxo-isopimara-8,15-diene (3), and 19-O-β-d-altropyranosyl-3,7-dioxo-isopimara-8(14),15-diene (4). The cytotoxic activity of the virescenosides was examined.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0305324