Sesquiterpene Phenylpropanoids from Ferula f ukanensis and Their Nitric Oxide Production Inhibitory Effects

Five new sesquiterpene phenylpropanoid derivatives, fukanedone A (1), fukanedone B (2), fukanedone C (3), fukanedone D (4), and fukanedone E (5), and a novel phenyl-oxo-acetate ester, fukaneketoester A (6), were isolated from a 80% aqueous methanol extract of the roots of Ferula fukanensis. The stru...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2005-03, Vol.68 (3), p.365-368
Main Authors: Motai, Tsunetake, Kitanaka, Susumu
Format: Article
Language:English
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Summary:Five new sesquiterpene phenylpropanoid derivatives, fukanedone A (1), fukanedone B (2), fukanedone C (3), fukanedone D (4), and fukanedone E (5), and a novel phenyl-oxo-acetate ester, fukaneketoester A (6), were isolated from a 80% aqueous methanol extract of the roots of Ferula fukanensis. The structures were elucidated on the basis of spectroscorpic evidence, especially heteronuclear multiple-bond connectivity (HMBC) and high-resolution MS. The sesquiterpene phenylpropanoid derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-γ (IFN-γ).
ISSN:0163-3864
1520-6025
DOI:10.1021/np040215c