Anti-babesial and Anti-plasmodial Compounds from Phyllanthus n iruri

Bioassay-guided fractionation of boiled aqueous extracts from the whole plant of Phyllanthus niruri led to the isolation of 1-O-galloyl-6-O-luteoyl-α-d-glucose (1), with IC50 values of 4.7 μg/mL against Babesia gibsoni and 1.4 μg/mL against Plasmodium falciparum in vitro. The known compounds β-gluco...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2005-04, Vol.68 (4), p.537-539
Main Authors: Subeki, Matsuura, Hideyuki, Takahashi, Kosaku, Yamasaki, Masahiro, Yamato, Osamu, Maede, Yoshimitsu, Katakura, Ken, Kobayashi, Sumiko, Trimurningsih, Chairul, Yoshihara, Teruhiko
Format: Article
Language:English
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Summary:Bioassay-guided fractionation of boiled aqueous extracts from the whole plant of Phyllanthus niruri led to the isolation of 1-O-galloyl-6-O-luteoyl-α-d-glucose (1), with IC50 values of 4.7 μg/mL against Babesia gibsoni and 1.4 μg/mL against Plasmodium falciparum in vitro. The known compounds β-glucogallin (2), quercetin 3-O-β-d-glucopyranosyl-(2→1)-O-β-d-xylopyranoside (3), β-sitosterol, and gallic acid were also isolated. Structures of these compounds were elucidated on the basis of their chemical and spectroscopic data.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0497245