A Cytotoxic Carotenoid from the Marine Sponge Prianos o siros

Investigations of the marine sponge Prianos osiros, collected in Pohnpei, gave a new cytotoxic acetylenic carotenoid, (3R,3‘R,5S)-3,3‘,5,19‘-tetrahydroxy-7‘,8‘-didehydro-γ,ε-carotene-8-one. The absolute configuration of this carotenoid was solved by interpretation of IR, MS, and 2D NMR spectra and a...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2005-03, Vol.68 (3), p.450-452
Main Authors: Rogers, Evan W, Molinski, Tadeusz F
Format: Article
Language:English
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Summary:Investigations of the marine sponge Prianos osiros, collected in Pohnpei, gave a new cytotoxic acetylenic carotenoid, (3R,3‘R,5S)-3,3‘,5,19‘-tetrahydroxy-7‘,8‘-didehydro-γ,ε-carotene-8-one. The absolute configuration of this carotenoid was solved by interpretation of IR, MS, and 2D NMR spectra and application of the modified Mosher's method. Compound 1 is cytotoxic toward cultured human colon tumor cells, HCT 116 (IC50 4.38 μg/mL).
ISSN:0163-3864
1520-6025
DOI:10.1021/np0497797